Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
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Nav1.1
(11)
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Nav1.2
(16)
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Nav1.3
(14)
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Nav1.4
(14)
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Nav1.5
(21)
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Nav1.6
(12)
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Nav1.7
(61)
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Nav1.8
(41)
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Nav1.9
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All Product Categories
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Sodium Channel Inhibitors
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Sodium Channel Agonists
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Sodium Channel Antagonists
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Sodium Channel Activators
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Sodium Channel Modulators
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Sodium Channel Controls
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Sodium Channel Ligands
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Sodium Channel Related Products (800)
Related Products (800)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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Bupivacaine (Standard)
0 ImagesBupivacaine (Standard) is the analytical standard of Bupivacaine. This product is intended for research and analytical applications. Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
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Dronedarone-d6
0 ImagesCat. No.: HY-A0016S3CAS No.: 1132693-87-8Synonyms: SR 33589-d6Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
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Propafenone-d7 hydrochloride
0 ImagesCat. No.: HY-B0432ASCAS No.: 1219799-06-0Synonyms: SA-79 D7 hydrochloridePropafenone-d7 (hydrochloride) is the deuterium labeled Propafenone, which is a classic anti-arrhythmic agent.
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Lamotrigine-d3
0 ImagesCat. No.: HY-B0495S5CAS No.: 1132746-94-1Synonyms: LTG-d3; BW430C-d3Lamotrigine-d3 is the deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al.
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Zorevunersen
0 ImagesSynonyms: STK-001Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome.
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Propafenone-d5 hydrochloride
0 ImagesCat. No.: HY-B0432AS2CAS No.: 1346605-05-7Propafenone-d5 (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79) hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias[1].
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5-(N,N-Hexamethylene)-amiloride (Standard)
0 ImagesSynonyms: Hexamethylene amiloride (Standard); HMA (Standard)5-(N,N-Hexamethylene)-amiloride (Standard) is the analytical standard of 5-(N,N-Hexamethylene)-amiloride. This product is intended for research and analytical applications. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.
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Flecainide hydrochloride (Standard)
0 ImagesCat. No.: HY-W010950ARCAS No.: 57415-44-8Flecainide hydrochloride is an orally active antiarrhythmic agent. Flecainide hydrochloride can block sodium channels and inhibit calcium ion release mediated by the cardiac ryanodine receptor (RyR2). Flecainide hydrochloride can be used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
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QX-314 bromide (Standard)
0 ImagesCat. No.: HY-101350RCAS No.: 24003-58-5QX-314 (bromide) (Standard) is the analytical standard of QX-314 (bromide) (HY-101350). This product is intended for research and analytical applications. QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
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BTS 39542
0 ImagesCat. No.: HY-126038CAS No.: 57410-31-8BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research.
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Co 102862 (Standard)
0 ImagesCat. No.: HY-108504RCAS No.: 181144-66-1Synonyms: V 102862 (Standard)
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Recainam (Standard)
0 ImagesCat. No.: HY-105454RCAS No.: 74738-24-2Synonyms: Wy-42362 (Standard)Recainam (Standard) is the analytical standard of Recainam. This product is intended for research and analytical applications. Recainam is a potent orally active antiarrhythmic agent and a sodium channel inhibitor. Recainam elevates ventricular fibrillation threshold, suppresses induced cardiac dysrhythmias, and may accentuate cardiac tissue refractoriness heterogeneity. Recainam can be used for the research of arrhythmias.
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NaV1.7 blocker-801
0 ImagesCat. No.: HY-116194CAS No.: 1235403-75-4NaV1.7 blocker-801 is a NaV1.7 channel blocker that can be used in the study of neurological diseases.
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Eslicarbazepine (Standard)
0 ImagesCat. No.: HY-114703RCAS No.: 104746-04-5Synonyms: BIA 2-194 (Standard)Eslicarbazepine (Standard) is the analytical standard of Eslicarbazepine. This product is intended for research and analytical applications. Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures.
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Fluphenazine-d6 hydrochloride
0 ImagesCat. No.: HY-119980BSFluphenazine-d6 (hydrochloride) is deuterium labeled Fluphenazine (hydrochloride). Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
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PF-04885614 (Standard)
0 ImagesCat. No.: HY-110325RCAS No.: 1480833-70-2PF-04885614 (Standard) is the analytical standard of PF-04885614 (HY-110325). This product is intended for research and analytical applications. PF-04885614 is a potent NaV1.8 inhibitor, extracted from patent US2018328915. PF-04885614 has potential for neurological and neurodevelopmental diseases treatment.
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Nav1.7-IN-3 (Standard)
0 ImagesCat. No.: HY-101789RCAS No.: 1788872-06-9Nav1.7-IN-3 (Standard) is the analytical standard of Nav1.7-IN-3 (HY-101789). This product is intended for research and analytical applications. Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration.
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Dibucaine hydrochloride (Standard)
0 ImagesSynonyms: Cinchocaine hydrochloride (Standard)Dibucaine (hydrochloride) (Standard) is the analytical standard of Dibucaine (hydrochloride). This product is intended for research and analytical applications. Dibucaine hydrochloride (Cinchocaine hydrochloride) is a sodium channel inhibitor. Dibucaine hydrochloride is a potent SChE inhibitor.
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Ajmaline (Standard)
0 ImagesSynonyms: Cardiorythmine (Standard); (+)-Ajmaline (Standard)Ajmaline (Standard) is the analytical standard of Ajmaline. This product is intended for research and analytical applications. Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia.
